MiR-499 inhibited hypoxia/reoxygenation induced cardiomyocytes injury by targeting SOX6
نویسندگان
چکیده
منابع مشابه
MiR-499-5p protects cardiomyocytes against ischaemic injury via anti-apoptosis by targeting PDCD4
Recent studies have reported that miRNAs might play critical roles in acute myocardial infarction (AMI). The objective of this study is to investigate the role of miR-499-5p in AMI and its potential molecular mechanisms. The expression level of MiR-499-5p was remarkably decreased in the infarcted myocardial tissues and in the cultured neonatal rat cardiomyocytes induced by hypoxia. Overexpressi...
متن کاملتاثیر فعالیت استقامتی بر بیان miR-499 و ژن Sox6 عضلات اسکلتی تند و کندانقباض
زمینه و هدف: فعالیت استقامتی بر عملکرد و همچنین عوامل درگیر در رونویسی عضلات اسکلتی درگیر تاثیر می‌گذارد. هدف این پژوهش بررسی تاثیر یک دوره فعالیت استقامتی بر بیان miR-499 و ژن sox6 در عضلات اسکلتی تند و کندانقباض رت‌های نر نژاد ویستار است. روش بررسی: بدین منظور 14 رت تحت شرایط کنترل شده نگهداری و سپس به صورت تصادفی به دو گروه کنترل و تجربی تقسیم شدند. گروه تجربی یک برنامه (14 هفته‌ای، 6 روز د...
متن کاملmiR-499 protects cardiomyocytes from H2O2-induced apoptosis via its effects on Pdcd4 and Pacs2
Background microRNAs (miRNAs) are a class of small, non-coding endogenous RNAs that post-transcriptionally regulate some protein-coding genes. miRNAs play an important role in many cardiac pathophysiological processes, including myocardial infarction, cardiac hypertrophy, and heart failure. miR-499, specifically expressed in skeletal muscle and cardiac cells, is differentially regulated and fun...
متن کاملThe investigation of miR-499 in apoptosis of cardiomyocytes in blood serum of MI patients
Background: Ischemic heart diseases (IHD) cause most deaths worldwide in a way that they are the cause of more than 30 percent of the deaths. After the discovery of miRNA in 1990 and the discovery of more than 2500 types of miRNA, gradually the importance of these mechanism regulators and molecular signals and gene routes were identified in the processes and the cellular mechanisms, especially ...
متن کاملMiR-499 Regulates Cell Proliferation and Apoptosis during Late-Stage Cardiac Differentiation via Sox6 and Cyclin D1
BACKGROUND MiR-499 is a cardiac-abundant miRNA. However, the biological functions of miR-499 in differentiated cardiomyocytes or in the cardiomyocyte differentiation process is not very clear. Sox6 is believed to be one of its targets, and is also believed to play a role in cardiac differentiation. Therefore, our aim was to investigate the association between Sox6 and miR-499 during cardiac dif...
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ژورنال
عنوان ژورنال: Biotechnology Letters
سال: 2019
ISSN: 0141-5492,1573-6776
DOI: 10.1007/s10529-019-02685-3